45. [IF=5.6] Wanli Ji et al."Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis."INTERNATIONAL IMMUNOPHARMACOLOGY".2024 May;132:111968 44. [IF=5.4] Wenjuan Ma et al."Uncovering the key pharmacodynamic material basis and possible molecular mechanism of Xiaoke formulation improve insulin resistant through a comprehensive investigation."JOURNAL OF ETHNOPHARMACOLOGY.2024 Apr;323:117752 43. [IF=7.9] Shan Zhang et al."Enhancing β-Cell Function and Identity in type 2 diabetes: The Protective Role of Coptis deltoidea C. Y. Cheng et Hsiao via Glucose Metabolism Modulation and AMPK Signaling Activation."PHYTOMEDICINE.2024 Jan;:155396 42. [IF=4.6] Yu Wang et al."Palmatine Protects PC12 Cells and Mice from Aβ25-35-Induced Oxidative Stress and Neuroinflammation via the Nrf2/HO-1 Pathway."MOLECULES.2023 Jan;28(24):7955 41. [IF=5.4] Botong Li et al."Protective effect of San Huang Pill and its bioactive compounds against ulcerative colitis in Drosophila via modulation of JAK/STAT, apoptosis, Toll, and Nrf2/Keap1 pathways."JOURNAL OF ETHNOPHARMACOLOGY.2024 Mar;322:117578 40. [IF=3.6] Jianning Zeng et al."Palmatine attenuates LPS-induced neuroinflammation through the PI3K/Akt/NF-κB pathway."JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY.2023 Oct;:e23544 39. [IF=4.6] Fengge YANG et al."Deciphering chemical and metabolite profiling of Chang-Kang-Fang by UPLC-Q-TOF-MS/MS and its potential active components identification."Chinese Journal of Natural Medicines.2023 Jun;21:459 38. [IF=5.4] Si-Min Pan et al."Baitouweng decoction repairs the intestinal barrier in DSS-induced colitis mice via regulation of AMPK/mTOR-mediated autophagy."JOURNAL OF ETHNOPHARMACOLOGY.2023 Jul;:116888 37. [IF=7.9] Jiangna Yan et al."Blocking LTB4 Signaling-mediated TAMs Recruitment by Rhizoma Coptidis Sensitizes Lung Cancer to Immunotherapy."PHYTOMEDICINE.2023 Jul;:154968 36. [IF=4.8] Mingyi Yao et al."In situ detection of natural dyes in archaeological textiles by SERS substrates immobilized on the fiber."MICROCHEMICAL JOURNAL.2023 Sep;192:108939 35. [IF=6.5] Wei Liu et al."Genome-wide analysis of bHLH gene family in Coptis chinensis provides insights into the regulatory role in benzylisoquinoline alkaloid biosynthesis."PLANT PHYSIOLOGY AND BIOCHEMISTRY.2023 Aug;201:107846 34. [IF=3.571] Ning Zhou et al."Exploring the efficacy mechanism and material basis of three processed Coptidis Rhizoma via metabolomics strategy."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2023 Aug;232:115450 33. [IF=6.656] Ning Zhou et al."Characterizing the specific mechanism of series processed Coptidis Rhizoma by multi-organ metabolomics combined with network pharmacology and molecular docking."PHYTOMEDICINE.2023 Jun;114:154804 32. [IF=3.614] Vinay Naithani et al."Preparation of open tubular capillary column covalently coated with polystyrene sulfonate with 4,4′-Azobis(4-cyanopentanoyl chloride) as polymerization initiator for electrochromatographic separation of alkaloids, sulfonamides, and p 31. [IF=2.724] Wanli Ji et al."Banxia Xiexin decoction ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis via inhibiting serine-threonine protein kinase (Akt)/mitogen-activated protein kinase (MAPK) signaling pathway."BIOTECHNOLOGY AND APPLIED BIOCHEMIS 30. [IF=0] Xiaoming Yin et al."Assessment of alkaloids from the stems of 14 Berberis species in China."Separation Science Plus.2022 Dec;:202200114 29. [IF=3.568] Hongyan Pei et al."Palmatine ameliorates LPS-induced HT-22 cells and mouse models of depression by regulating apoptosis and oxidative stress."JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY.2022 Sep;:e23225 28. [IF=2.838] Wang Shuo et al."Toxicity and toxicokinetics of the ethanol extract of Zuojin formula."BMC Complementary Medicine and Therapies.2022 Dec;22(1):1-14 27. [IF=6.656] Ye Yang et al."Coptis chinensis polysaccharides dynamically influence the paracellular absorption pathway in the small intestine by modulating the intestinal mucosal immunity microenvironment."PHYTOMEDICINE.2022 Sep;104:154322 26. [IF=7.291] Bu Junling et al."Catalytic promiscuity of O-methyltransferases from Corydalis yanhusuo leading to the structural diversity of benzylisoquinoline alkaloids."Horticulture Research.2022 Jul;: 25. [IF=5.165] Juanning Ren et al."Qualitative and quantitative analysis of multi-components in Xing-Su-Ning Capsules for quality improvement."Arab J Chem. 2022 Jun;15:103825 24. [IF=1.345] Ya-Li Zhang et al."Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells."J Asian Nat Prod Res. 2020;22(5):452-463 23. [IF=2.351] Juanjuan Liu et al."Antifungal evaluation of traditional herbal monomers and their potential for inducing cell wall remodeling in Candida albicans and Candida auris."Biofouling. 2020;36(3):319-331 22. [IF=3.373] Xueyan Zhao et al."An integrated strategy for the establishment of a protoberberine alkaloid profile: Exploration of the differences in composition between Tinosporae radix and Fibraurea caulis."Phytochem Analysis. 2021 Nov;32(6):1131-1140 21. [IF=3.463] Xiao-Meng Liu et al."Comparative transcriptome analysis provides novel insights into the molecular mechanism of berberine biosynthesis in Coptis chinensis."Sci Hortic-Amsterdam. 2022 Jan;291:110585 20. [IF=3.935] Yang Song et al."Pharmacokinetics, tissue distribution and plasma protein binding rate of palmatine following intragastric and intravenous administration in rats using liquid chromatography tandem mass spectrometry."J Pharmaceut Biomed. 2021 Sep;203:11422 19. [IF=3.963] Zhong-min Zhao et al."Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine."Pestic Biochem Phys. 2019 Sep;159:51 18. [IF=5.81] Zhao Jing et al."Intra-Herb Interactions: Primary Metabolites in Coptidis Rhizoma Extract Improved the Pharmacokinetics of Oral Berberine Hydrochloride in Mice."Front Pharmacol. 2021 Jun;0:1426 17. [IF=1.618] Li Jiang-Yan et al."Seasonal Variation of Alkaloid Contents and Anti-Inflammatory Activity of Rhizoma coptidis Based on Fingerprints Combined with Chemometrics Methods."J Chromatogr Sci. 2015 Aug;53(7):1131-1139 16. [IF=2.896] Shun Liu et al."Effects of ultrahigh pressure extraction conditions on yields of berberine and palmatine from cortex Phellodendri amurensis."Anal Methods-Uk. 2013 Aug;5(17):4506-4512 15. [IF=3.659] Rong Qian et al."In vitro and in vivo bactericidal activity of Tinospora sagittata (Oliv.) Gagnep. var. craveniana (S.Y.Hu) Lo and its main effective component, palmatine, against porcine Helicobacter pylori."Bmc Complem Altern M. 2016 Dec;16(1):1-8 14. [IF=3.935] Ka-Yan Kwok et al."Quality evaluation of commercial Huang-Lian-Jie-Du-Tang based on simultaneous determination of fourteen major chemical constituents using high performance liquid chromatography."J Pharmaceut Biomed. 2013 Nov;85:239 13. [IF=4.411] Jinjun Shan et al."Liquid Chromatography Coupled with Linear Ion Trap Hybrid OrbitrapMass Spectrometry for Determination of Alkaloids in Sinomeniumacutum."Molecules. 2018 Jul;23(7):1634 12. [IF=4.759] Yanyan Zhang et al."Rapid screening and identification of monoamine oxidase-A inhibitors from Corydalis Rhizome using enzyme-immobilized magnetic beads based method."J Chromatogr A. 2019 May;1592:1 11. [IF=4.759] Yu-Xiu Yang et al."pH-dependent surface electrostatic effects in retention on immobilized artificial membrane chromatography: Determination of the intrinsic phospholipid-water sorption coefficients of diverse analytes."J Chromatogr A. 2018 Oct;1570:172 10. [IF=6.057] Zhihong Li et al."New MS network analysis pattern for the rapid identification of constituents from traditional Chinese medicine prescription Lishukang capsules in vitro and in vivo based on UHPLC/Q-TOF-MS."Talanta. 2018 Nov;189:606 9. [IF=6.331] Thanh Xuan Nguyen et al."Chitosan-coated nano-liposomes for the oral delivery of berberine hydrochloride."J Mater Chem B. 2014 Oct;2(41):7149-7159 8. Chen, Meng, et al. "Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate." Journal of Pharmaceutical and Biomedical Analysis 195 (2021): 113820.https:// 7. Nguyen, Thanh Xuan, et al. "Chitosan-coated nano-liposomes for the oral delivery of berberine hydrochloride." Journal of Materials Chemistry B 2.41 (2014): 7149-7159.https://doi.org/10.1039/C4TB00876F 6. Wang, Kun, et al. "Identification of metabolites of palmatine in rats after oral administration using ultra‐high‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry." Rapid Communications in Mass Spectrometry 31.6 (2017): 523-537. 5. 晏余,陈维佳,赵岩,宗颖,时坤,何忠梅,杜锐.黄藤总生物碱固体分散体在小鼠体内吸收的药代动力学及相对生物利用度[J].吉林农业大学学报,2021,43(01):75-81. 4. 刘珍珍 白桥 徐皓. 不同初加工方法对延胡索5种生物碱含量的影响[J]. 现代农业科技 2019 000(022):173-176. 3. 严赟, 张赟赟. HPLC-ESI-MS/MS同时测定金果榄中5种成分含量[J]. 中药材, 2017, 40(002):395-398. 2. 张赟赟,李嘉.HPLC-ESI-MS/MS法同时测定金线风中7种有效成分[J].中华中医药杂志,2017,32(06):2762-2764. 1. 闫宝琪, 董书伟, 王东升,等. 黄藤素对山羊子宫内膜上皮细胞的体外毒性研究[J]. 中国畜牧兽医, 2016, 43(012):3239-3244.