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酮康唑

    
分析标准品,HPLC≥98%

Ketoconazole

源叶
B24154 一键复制产品信息
65277-42-1
C26H28Cl2N4O4
531.43
MFCD00058579
酮亢唑;顺-1-乙酰基-4-[4-[[2-(2,4-二氯苯基)-2-(1H-咪唑-1-基甲基)-1,3-二氧戊环-4-基]甲氧基]苯基]哌嗪
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
B24154-100mg促销
分析标准品,HPLC≥98%

¥200.00 ¥140.00

9 3 3 - 1
产品介绍 参考文献(40篇) 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

 Ketoconazole (R-41400) 是咪唑类抗真菌剂,是经典的CYP3A4抑制剂,也是 CYP24A1的抑制剂。

SMILES: ClC1=CC=C([C@]2(CN3C=CN=C3)OC[C@@H](COC4=CC=C(N5CCN(C(C)=O)CC5)C=C4)O2)C(Cl)=C1
熔点: 146°C
沸点: 753.4 °C at 760 mmHg
比旋光度: -10.5 ° (C=0.4, CHCl3)
外观: 白色结晶性粉末
溶解性: DMSO  :  10  mg/mL  (47.04  mM;  Need  ultrasonic)
敏感性: 对热敏感
储存条件: 2-8℃
密度: 1.38
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献(40篇)

35. [IF=2.9] Jianping Liang et al."Dose-dependent modulation of hepatic cytochrome P450 enzymes by tenvermectin: implications for medication safety and combination therapy."Frontiers in Veterinary Science.2025 Aug;12:1647697 34. [IF=2.9] Jianping Liang et al."Dose-dependent modulation of hepatic cytochrome P450 enzymes by tenvermectin: implications for medication safety and combination therapy."Frontiers in Veterinary Science.2025 Aug;12:1647697 33. [IF=5.6] Kaiqi Shang et al."Kokusaginine metabolism in rats: A comparative in Vitro-In vivo analysis revealing sex-dependent differences."BIOCHEMICAL PHARMACOLOGY.2025 Jun;:117092 32. [IF=3.1] Xiaofei Chen et al."Mechanistic insights into Licorice-Evodiae Fructus interaction: UPLC-MS/MS-based hepatotoxic metabolite detection and CYP3A4 regulation study."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2025 Oct;264:116985 31. [IF=2.9] Jinqiu Rao et al."Inactivation of CYP2D6 by Berberrubine and the Chemical Mechanism."BIOCHEMISTRY.2024;XXXX(XXX):XXX-XXX 30. [IF=2.2] Zhaowei Jin et al."Ketoconazole-loaded microspone film coating agent for superficial fungal infection: design, preparation and characterization."JOURNAL DE MYCOLOGIE MEDICALE.2025 Apr;:101551 29. [IF=5.3] Yujie Yang et al."Amphiphilic disodium glycyrrhizin as a co-former for ketoconazole co-amorphous systems: Biopharmaceutical properties and underlying molecular mechanisms."INTERNATIONAL JOURNAL OF PHARMACEUTICS.2024 Sep;:124673 28. [IF=12.2] Tingting Chai et al."Multidimensional occurrence and diet risk of emerging contaminants in freshwater with urban agglomerations."JOURNAL OF HAZARDOUS MATERIALS.2024 Aug;474:134813 27. [IF=3.5] Jiang-Yu Long et al."Effect of cytochrome P450 3A4 on tissue distribution of humantenmine, koumine, and gelsemine, three alkaloids from the toxic plant Gelsemium."TOXICOLOGY LETTERS".2024 Jun;397:34 26. [IF=7.9] Jiapan Gao et al."In vitro pharmacokinetic behavior in lung of harringtonine, an antagonist of SARS-CoV-2 associated proteins: New insights of inhalation therapy for COVID-19."PHYTOMEDICINE".2024 Apr;:155582 25. [IF=8.4] Wei Cai et al."Rational design of α-glucosidase activated near-infrared fluorescent probe and its applications in diagnosis and treatment of diabetes."SENSORS AND ACTUATORS B-CHEMICAL.2024 Feb;400:134878 24. [IF=5.2] Siyi Li et al."Safety evaluation, hydrolysis activity of Kluyveromyces marxianus JY-1 and its application to obtain immunomodulatory peptide from bovine casein."Food Bioscience.2023 Dec;56:103409 23. [IF=4.3] Peng Ting et al."Elucidation of the relationship between evodiamine-induced liver injury and CYP3A4-mediated metabolic activation by UPLC-MS/MS analysis."ANALYTICAL AND BIOANALYTICAL CHEMISTRY.2023 Jul;:1-17 22. [IF=5.6] Wang Hanxue et al."Metabolism and toxicity of usnic acid and barbatic acid based on microsomes, S9 fraction, and 3T3 fibroblasts in vitro combined with a UPLC-Q-TOF-MS method."Frontiers in Pharmacology.2023 Jun;14: 21. [IF=5.988] Qun Wang et al."Study on the liver Drug’s dominant metabolic enzymes for six effective components of the Huang qi Liuyi decoction."Frontiers in Pharmacology.2023; 14: 1175896 20. [IF=2.041] Huiling Chen et al."Ferulic acid prevents Diosbulbin B-induced liver injury by inhibiting covalent modifications on proteins."Drug Metabolism and Pharmacokinetics.2023 Mar;:100507 19. [IF=6.656] Jie Pan et al."Difference in hepatotoxicity of furan-containing components in cortex dictamni correlates the efficiency of their metabolic activation."PHYTOMEDICINE.2023 Jun;114:154778 18. [IF=6.656] Yanchao Xing et al."Cytochrome P450-mediated herb-drug interaction (HDI) of Polygonum multiflorum Thunb. based on pharmacokinetic studies and in vitro inhibition assays."PHYTOMEDICINE.2023 Feb;:154710 17. [IF=8.008] Jieqing Feng et al."Online Pressure Change Focusing-Supercritical Fluid Selective Extraction Chromatography for Analyzing Chiral Drugs in Microliter-Scale Plasma Samples."ANALYTICAL CHEMISTRY.2022;XXXX(XXX):XXX-XXX 16. [IF=4.014] Ziyong Xu et al."Chicken xenobiotic receptor upregulates the BCRP/ABCG2 transporter."POULTRY SCIENCE.2022 Oct;:102278 15. [IF=5.222] Mei Li et al."Potential Pharmacokinetic Effect of Chicken Xenobiotic Receptor Activator on Sulfadiazine: Involvement of P-glycoprotein Induction."Antibiotics-Basel.2022 Aug;11(8):1005 14. [IF=3.5] Ying-huan Hu et al."Inhibition of CYP3A4 enhances aloe-emodin induced hepatocyte injury."Toxicol In Vitro. 2021 Dec;:105276 13. [IF=1.663] Wei Huang et al."Effects of osthol on activity, mRNA and protein expression of Cyp3a in rats in vivo."Biopharm Drug Dispos. 2020 Feb;41(1-2):64-71 12. [IF=5.076] Liu Zi-Jing et al."The Alexipharmic Mechanisms of Five Licorice Ingredients Involved in CYP450 and Nrf2 Pathways in Paraquat-Induced Mice Acute Lung Injury."Oxid Med Cell Longev. 2019;2019:7283104 11. [IF=4.411] Xu Zhang et al."In Vitro and In Situ Characterization of the Intestinal Absorption of Capilliposide B and Capilliposide C from Lysimachia capillipes Hemsl."Molecules. 2019 Jan;24(7):1227 10. Huang, Wei, et al. "Effects of osthol on activity, mRNA and protein expression of Cyp3a in rats in vivo." Biopharmaceutics & drug disposition 41.1-2 (2020): 64-71.https://doi.org/10.1002/bdd.2214 9. Huang, Wei, et al. "Effects of osthol on activity, mRNA and protein expression of Cyp3a in rats in vivo." Biopharmaceutics & drug disposition 41.1-2 (2020): 64-71.https://doi.org/10.1002/bdd.2214 8. 陈瑞,周维,张丽,朱高峰,黄静,汤磊.树豆酮酸A对人肝微粒体中5种常见细胞色素P_(450)酶的体外抑制作用研究[J].中国药房,2021,32(02):195-200. 7. 王呈谕,李登科,全正扬,胡英还,孙震晓.基于细胞色素氧化酶CYP2D6的何首乌肝细胞毒性及相关成分研究[J].中国药物警戒,2021,18(03):220-227+239. 6. 马晓平, 杨秋霞, 俞演,等. 大熊猫源枝孢样枝孢霉野生株(Z20)与突变株(Zt)部分生物学特性及药敏试验比较[J]. 浙江农业学报, 2018(8):1328-1335. 5. 彭彦, 杨超, 姜尧章,等. 肉牛源细极链格孢菌的分离鉴定[J]. 中国预防兽医学报, 2020, v.42(01):86-89+99. 4. 钟晶, 左晓婷, 王晓琴,等. 甘草四种活性成分药酶诱导作用研究[J]. 石河子大学学报:自然科学版, 2016, 34(004):468-472. 3. 周国坚,叶董婷,邓旭杏.板蓝根颗粒、茵栀黄颗粒和复方黄连素片对药物代谢酶CYP_3A_4活性的影响[J].中医药导报,2017,23(03):72-74. 2. 周国坚, 叶董婷, 邓旭杏. 黄连上清丸,护肝片及牛黄解毒丸对药物代谢酶CYP3A4活性的影响[J]. 中国民族民间医药, 2016, 10(v.25;No.279):22-24. 1. 周国坚,叶董婷,邓旭杏.银黄颗粒、牛黄上清丸、双黄连合剂对药物代谢酶CYP_3A_4活性的影响[J].亚太传统医药,2016,12(15):19-22.

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