环孢菌素A

分析标准品,Purity≥98%

Cyclosporin A

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品牌：源叶

产品编号：B28163 一键复制产品信息

CAS号：59865-13-3

分子式：C₆₂H₁₁₁N₁₁O₁₂

分子量：1202.61

MDL：MFCD00274558

别名：环孢霉素A;环孢多肽A;环孢灵;环孢素;环胞霉素A;抗生素S7481F1;环孢多肽A

货号	规格	价格	上海	北京	武汉	南京	购买数量
B28163-20mg	分析标准品,Purity≥98%	￥500.00 B28163-20mg ￥500.00 现货	4 0 4	-	-	-

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产品介绍参考文献(34篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品介绍

Cyclosporin A (Cyclosporine A) 是一种免疫抑制剂，能与亲环素结合，抑制 calcineurin 活性的IC50 值为 7 nM。Cyclosporin A 也抑制 CD11a/CD18 粘附分子。

熔点：	151°C
沸点：	1293.8±65.0 °C at 760 mmHg
比旋光度：	D20 -244° (c = 0.6 in chloroform); D20 -189° (c = 0.5 in methano
外观：	白色针状结晶
溶解性：	DMSO : 62.5 mg/mL (51.97 mM; Need ultrasonic) Ethanol : 50 mg/mL (41.58 mM; Need ultrasonic)
储存条件：	2-8℃
注意：	部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(34篇)

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29. [IF=10.5] Yifan Zhou et al."Hybrid membrane-coated Cyclosporine A nanocrystals preventing secondary brain injury via alleviating neuroinflammatory and oxidative stress."JOURNAL OF CONTROLLED RELEASE.2025 Apr;:113795 28. [IF=4.2] Ting Lu et al."18β-Glycyrrhetinic acid synergizes with enzalutamide to counteract castration-resistant prostate cancer by inhibiting OATP2B1 uptake of dehydroepiandrosterone."EUROPEAN JOURNAL OF PHARMACOLOGY.2024 Sep;:176995 27. [IF=2] Hu Shan-shan et al."Icariin Ameliorates D-galactose-induced Cell Injury in Neuron-like PC12 Cells by Inhibiting MPTP Opening."Current Medical Science.2024 Jun;:1-11 26. [IF=6] Zhou Zhiyong et al."Icariin improves oxidative stress injury during ischemic stroke via inhibiting mPTP opening."MOLECULAR MEDICINE.2024 Dec;30(1):1-14 25. [IF=4.9] Mengting Xiong et al."Cyclosporine A-loaded colon-targeted oral nanomicelles self-assembly by galactosylated carboxymethyl chitosan for efficient ulcerative colitis therapy."EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS.2023 Aug;189:152 24. [IF=6.51] Ziqin Cao et al."In situ formation of injectable organogels for punctal occlusion and sustained release of therapeutics: design, preparation, in vitro and in vivo evaluation."INTERNATIONAL JOURNAL OF PHARMACEUTICS.2023 May;638:122933 23. [IF=14.957] Ruirui Xing et al."Biomolecular glass with amino acid and peptide nanoarchitectonics."Science Advances.2023 Mar;9(11) 22. [IF=2.488] Xin Liu et al."Microbial and chemical transformations of euphorbia factor L1 and the P-glycoprotein inhibitory activity in zebrafishes."NATURAL PRODUCT RESEARCH 21. [IF=9.429] Liu Daozhou et al."Cyclosporine A loaded brain targeting nanoparticle to treat cerebral ischemia/reperfusion injury in mice."JOURNAL OF NANOBIOTECHNOLOGY.2022 Dec;20(1):1-17 20. [IF=9.429] Li Fangyuan et al."Tregs biomimetic nanoparticle to reprogram inflammatory and redox microenvironment in infarct tissue to treat myocardial ischemia reperfusion injury in mice."JOURNAL OF NANOBIOTECHNOLOGY.2022 Dec;20(1):1-21 19. [IF=3.981] Xiao-Hang Liu et al."Comparison of the permeability between conjugated estrogens and atenolol in rat in situ single-pass intestinal perfusions model and in Caco-2 cell monolayers."J Drug Deliv Sci Tec. 2022 Feb;68:102786 18. [IF=5.923] Yue Gao et al."Human IL-23R Cytokine-Binding Homology Region-Fc Fusion Protein Ameliorates Psoriasis via the Decrease of Systemic Th17 and ILC3 Cell Responses."Int J Mol Sci. 2019 Jan;20(17):4170 17. [IF=1.627] Yanming Xia et al."Transport mechanism of ursodeoxycholic acid in human placental BeWo cells."Biopharm Drug Dispos. 2018 Jul;39(7):335-343 16. [IF=2.368] Baihuan Feng et al."Exposure to a 50-Hz magnetic field induced mitochondrial permeability transition through the ROS/GSK-3β signaling pathway."Int J Radiat Biol. 2016;92(3):148-155 15. [IF=4.411] Xu Zhang et al."In Vitro and In Situ Characterization of the Intestinal Absorption of Capilliposide B and Capilliposide C from Lysimachia capillipes Hemsl."Molecules. 2019 Jan;24(7):1227 14. [IF=10.435] Zhang Chang-xiong et al."Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats."J Nanobiotechnol. 2019 Dec;17(1):1-16 13. Feng, Baihuan, et al. "Exposure to a 50-Hz magnetic field induced mitochondrial permeability transition through the ROS/GSK-3β signaling pathway." International journal of radiation biology 92.3 (2016): 148-155.https://doi.org/10.3109/09553002.2016.1135261 12. 林琳,曹俊昌,杨政,冯春燕.0.05%环孢素A纳米粒滴眼液治疗干眼症的实验研究[J].中医眼耳鼻喉杂志,2021,11(01):1-5. 11. 郭鑫, 王桃, 石岩,等. 驻极体外静电场对不同参数环孢菌素A贴剂极化特性的影响[J]. 北京理工大学学报, 2017, 37(002):191-195. 10. 刘鸿越, 江键, 马琳,等. 驻极体及联用氮酮对环孢菌素A的体外透皮促渗作用[J]. 药学实践杂志, 2012, 30(006):440-442. 9. 郭鑫, 崔黎丽, 梁媛媛,等. 负极性驻极体环孢菌素A贴剂的压电性[J]. 高电压技术, 2014, 040(006):1916-1920. 8. 孟治平, 路曼琪, 苏文强,等. 盐酸小檗碱粉雾剂的制备及其对金黄色葡萄球菌肺炎的作用研究[J]. 中草药, 2020, v.51;No.661(02):73-80. 7. 左霞, 郭俐宏, 李莉. 百令胶囊对肾移植大鼠肾功能及排斥反应的影响[J]. 现代中西医结合杂志, 2015(12):1279-1282. 6. 李方园, 刘道洲, 刘苗,等. 活性氧响应负载环孢菌素A纳米粒对缺氧/复氧损伤心肌细胞的保护作用[J]. 西北药学杂志, 2020, 035(002):229-233. 5. 黄平, 石岩, 郭鑫,等. 正极性驻极体环孢菌素A贴剂的开路热刺激放电[J]. 高电压技术, 2015. 4. 梁媛媛, 马琳, 崔黎丽,等. 正极性驻极体和氮酮对环孢素A的体外透皮促渗作用[J]. 第二军医大学学报, 2012(06):617-620. 3. 邓成程, 李倩, 唐军,等. 普朗尼克对多西他赛耐药的人乳腺癌细胞毒性及摄取的影响[J]. 中国药师, 2018, 21(008):1325-1330. 2. 赵静.人参皂苷Rg_1对糖基化末端产物诱导肾小球系膜细胞炎症及TGFβ/Smad信号通路的影响[J].中国药师 2018 21(11):1919-1923. 1. 李倩王明邓成程等. 两亲性嵌段共聚物普朗尼克的细胞毒性及细胞摄取[J]. 中国医院药学杂志 2017 37(12):1124-1128.

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