货号	规格	价格	上海	北京	珠海	重庆	武汉
S47249-5mg促销	相对分子量标准品，1046	￥270.00 ￥216.00 S47249-5mg ￥216.00 现货	4 5 4	2	2	-	1
S47249-25mg促销	相对分子量标准品，1046	￥560.00 ￥448.00 S47249-25mg ￥448.00 现货	2 2	-	-	-	-
S47249-100mg促销	相对分子量标准品，1046	￥1600.00 ￥1280.00 S47249-100mg ￥1280.00 现货	4 4	-	-	-	-

产品介绍

Angiotensin II (Angiotensin II) 是一种血管收缩剂，是肾素/血管紧张素系统的主要生物活性肽。Angiotensin II human 在调节人类血压中起着核心作用，主要通过血管紧张素 II 与 G 蛋白偶联受体 (GPCRs)、血管紧张素II 1型受体 (AT1R) 和血管紧张素II 2型受体 (AT2R) 之间的相互作用来介导。Angiotensin II human 刺激交感神经刺激，增加醛固酮生物合成和肾脏活动。Angiotensin II human 诱导血管平滑肌细胞生长，增加成纤维细胞中 I 型和 III 型胶原的合成，导致血管壁和心肌增厚，并导致纤维化。Angiotensin II human 也诱导细胞凋亡 (apoptosis)。Angiotensin II human 通过 LOX-1 依赖的氧化还原敏感途径诱导内皮细胞毛细血管形成。

【Sequence】
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
DRVYIHPF

SMILES：	O=C([C@H](CC1=CN=CN1)NC([C@H]([C@@H](C)CC)NC([C@H](CC1C=CC(=CC=1)O)NC([C@H](C(C)C)NC([C@H](CCC/N=C(N)/N)NC([C@H](CC(=O)O)N)=O)=O)=O)=O)=O)N1CCC[C@H]1C(N[C@H](C(=O)O)CC1C=CC=CC=1)=O
溶解性：	Soluble in Water (25 mg/ml), and 5% Acetic Acid (1 mg/ml).
敏感性：	热敏感
储存条件：	-20℃
用途：	A peptide involved in the regulation of blood pressure
密度：	1.43
注意：	部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(20篇)

20. [IF=5.4] Qiongqiong Zhao, et al. "Kaempferol Alleviates Right Ventricular Hypertrophy in High Altitude Pulmonary Hypertension Rats by Modulating AMPK/ACC/CPT1B Axis and AMPK-mediated LDHA/PDHA1 Pathway"Food & Function, 2026 Feb;: 19. [IF=3.5] Lu Zhang, et al. "Multidimensional study of DPP-IV inhibitory peptides from phycocyanin: Screening, identification, inhibitory mechanism, hypoglycemic activity in vivo and cellular transportation"JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2026 Apr;: 18. [IF=5.4] Changyu Lei et al."Pharmacodynamic substances and molecular mechanisms of Tsantan Sumtang alleviating hypoxic pulmonary vascular remodeling."JOURNAL OF ETHNOPHARMACOLOGY.2026 Jan;355:120585 17. [IF=4.7] Bin Hou et al."Luteolin alleviates right ventricular hypertrophy in high altitude pulmonary hypertension rats by regulating PI3K/AKT/mTOR signalling pathway."EUROPEAN JOURNAL OF PHARMACOLOGY.2025 Jul;:177898 16. [IF=1.1] Tian Zexiang et al."WTAP-mediated m6A modification on BASP1 mRNA contributes to ferroptosis in AAA."General Thoracic and Cardiovascular Surgery.2025 Feb;:1-10

15. [IF=7.7] Ruixue Rong et al."LncRNA NAV2-AS2 is critical for fibroblast-to-myofibroblast transition and cardiac fibrosis."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2025 May;306:141400 14. [IF=5.1] Yuting Shang et al."Study on the mechanism of mitigating radiation damage by improving the hematopoietic system and intestinal barrier with Tenebrio Molitor peptides."Food & Function.2024 Jul;: 13. [IF=1.5] Kelian Zhang et al."Astaxanthin Alleviates the Process of Cardiac Hypertrophy by Targeting the METTL3/Circ_0078450/MiR-338-3p/GATA4 Pathway."International Heart Journal.2024 Jan;65(1):119-127 12. [IF=3.5] Xianzhao Cao et al."CircNRIP1 promotes proliferation, migration and phenotypic switch of Ang II-induced HA-VSMCs by increasing CXCL5 mRNA stability via recruiting IGF2BP1."AUTOIMMUNITY. 11. [IF=8] Xianrui Song et al."Intravenous Injection of Na Ions Aggravates Ang II-Induced Hypertension-Related Vascular Endothelial Injury by Increasing Transmembrane Osmotic Pressure."International Journal of Nanomedicine. 10. [IF=0.7] Li Ya et al."Asiaticoside promotes heart autonomic nerve repair through receptor activator of nuclear factor kappa-B ligand pathway in coronary heart disease."Materials Express.2023 Jul;13(7):1301-1307 9. [IF=2.1] Jin Shu et al."Matrix metalloproteinase 3 regulates angiotensin II‑induced myocardial fibrosis cell viability, migration and apoptosis."Mol Med Rep. 2021 Feb;23(2):1-1 8. [IF=4.868] Nie Pei et al."Astragaloside IV Exerts a Myocardial Protective Effect against Cardiac Hypertrophy in Rats, Partially via Activating the Nrf2/HO-1 Signaling Pathway."Oxid Med Cell Longev. 2019;2019:4625912 7. [IF=5.118] Shan-Shan Zhang et al."Two Novel Multi-Functional Peptides from Meat and Visceral Mass of Marine Snail Neptunea arthritica cumingii and Their Activities In Vitro and In Vivo."Mar Drugs. 2018 Dec;16(12):473 6. Nie, Pei, et al. "Astragaloside IV exerts a myocardial protective effect against cardiac hypertrophy in rats, partially via activating the Nrf2/HO-1 signaling pathway." Oxidative medicine and cellular longevity 2019 (2019).https://doi.org/10.1155/2019/4625 5. 聂佩,孟凡静,张金国,尉希清.黄芪甲苷抑制血管紧张素Ⅱ诱导的心肌H9c2细胞凋亡[J].中国病理生理杂志,2019,35(11):1942-1950. 4. 匡聪, 贾俊强, 吴琼英,等. 超声-离子液体处理对乳清蛋白酶解动力学及其产物抗氧化活性的影响[J]. 食品科学, 2017(23):32-38. 3. 刘晓瑜,程赛博,徐煜凌,何培坤,顾民华,周凤华,贾钰华.基于ACE2-Ang(1-7)-Mas轴探讨定心方三号方改善人脐静脉内皮细胞功能的机制研究[J].中药新药与临床药理,2019,30(03):301-307. 2. 阮旭杨晔徐仲儒等. 丹参注射液对AngⅡ诱导NRK-52E细胞损伤的保护作用[J]. 中成药 2018 040(005):1170-1173. 1. 郑伟常虎林海军宋晓雪杜立学.Ang Ⅱ通过激活Notch1/Sox2通路对肝星状细胞LX2的活化和增殖的作用[J].中华细胞与干细胞杂志(电子版) 2018 8(03):156-160.

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血管紧张素II

Angiotensin Ⅱ, human