93. [IF=4.8] Bin-Chun Li et al."Characterization of a Thermophilic and Acidophilic GH78 α-L-Rhamnosidase from Thermotoga sp. 2812B Capable of Efficiently Hydrolyzing a Variety of Natural Flavonoid Diglycosides."Biomolecules.2025 Dec;16(1):68 92. [IF=2.6] Hongping Wang et al."Global profiling of α-glucosidase inhibitors from Citri Reticulatae Pericarpium based on affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS method."PLoS One.2026 Jan;21(1):e0340990 91. [IF=4] Wenhua Hou et al."(+)-Catechin from Prunus padus disrupts detoxification pathways and provides field-level control of the bird cherry-oat aphid, Rhopalosiphum padi."PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY.2026 Jan;:106956 90. [IF=6.2] Dewei He et al."Orally Administered Neohesperidin (Neo) Alleviates Lipopolysaccharide-Induced Mastitis by Suppressing TLR4/NF-κB and Activating AMPK/Nrf2/HO-1 Signaling, and Regulating Intestinal Flora Structure."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 89. [IF=8] Weijie Wang et al."Metabolomics combined with extraction optimization and biochemical assays revealed flavonoids and in vitro and in vivo antioxidant activity of Ponkan Chenpi."FOOD RESEARCH INTERNATIONAL.2026 Mar;227:118324 88. [IF=2.8] Jiaxue Wang et al."Metabolic and pharmacokinetic differences of Huai Hua san in Sprague Dawley and ulcerative colitis rats."JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES.2025 Sep;:124802 87. [IF=5.1] Yifan Liu et al."Preparation of hapten and monoclonal antibody of diosmin and establishment of enzyme-linked immunosorbent assay."MICROCHEMICAL JOURNAL.2025 Nov;218:115257 86. [IF=4.7] Xialin Guo et al."Lasso regression with molecular descriptors predicts natural product adsorption onto graphene oxide-derived adsorbents."MATERIALS CHEMISTRY AND PHYSICS.2026 Jan;347:131419 85. [IF=7] Sheng Geng et al."Formation mechanism and characterization of hesperidin-stabilized Pickering emulsion gels."Current Research in Food Science.2025 Jan;11:101225 84. [IF=4.7] Xialin Guo et al."Lasso regression with molecular descriptors predicts natural product adsorption onto graphene oxide-derived adsorbents."MATERIALS CHEMISTRY AND PHYSICS.2026 Jan;347:131419 83. [IF=8.5] Yaoguang Huang et al."Orange debittering by a novel thermostable flavonoid glycosidase."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2025 Sep;321:146403 82. [IF=1.7] Jie Gao et al."Comprehensive Investigation of Homology and Heterogeneity Between Aurantii Fructus and Aurantii Fructus Immaturus Using Chemometrics Combined with Network Pharmacology."JOURNAL OF MEDICINAL FOOD. 81. [IF=4.9] Bingjing Xu et al."RDA-direct targeted flavonoids profiling strategy combined with fingerprinting and chemometrics for quality evaluation of Changshan Huyou flower."MICROCHEMICAL JOURNAL.2025 May;212:113204 80. [IF=4.3] Ganjun Yuan et al."One Earth-One Health (OE-OH): Antibacterial Effects of Plant Flavonoids in Combination with Clinical Antibiotics with Various Mechanisms."Antibiotics-Basel.2025 Jan;14(1):8 79. [IF=3] Chen Huang et al."A Comprehensive Quality Evaluation Strategy of Wendan Decoction Based on Qualitative, Fingerprint, and Quantitative Analyses."PHYTOCHEMICAL ANALYSIS.2025 Feb;: 78. [IF=1.3] Lili Liu et al."Inhibitory Effect of Ponkan (Citrus reticulata ‘Ponkan’) Flavonoids on Oral Ulcers through Jak2-Stat3 Signaling Pathway."PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY.2024 Sep;93:2499 77. [IF=1.4] Di Wu et al."Hesperidin and 5, 7-dimethoxycoumarin act as markers in the chemotaxonomy of Citrus medica L. var. sarcodactylis Swingle and Citrus medica L.."BIOCHEMICAL SYSTEMATICS AND ECOLOGY.2024 Dec;117:104900 76. [IF=5.6] Yifan Liu et al."Preparation of hapten and monoclonal antibody of hesperetin and establishment of enzyme-linked immunosorbent assay."TALANTA.2025 Jan;281:126912 75. [IF=5.6] Yifan Liu et al."Preparation of monoclonal antibody against rhoifolin and its application in enzyme-linked immunosorbent assay of rhoifolin and diosmin."TALANTA.2025 Jan;281:126871 74. [IF=4.8] Desheng Wu et al."Discovery of specific inhibitors of Porphyromonas gingivalis gingipains from food-derived flavonoids by high-throughput virtual screening and molecular simulations."Food Bioscience.2024 Oct;61:104596 73. [IF=7] Xin Huang et al."The effects of core microorganism community on flavor compounds and active substances during the aging process of Citri Reticulatae Pericarpium."FOOD RESEARCH INTERNATIONAL.2024 Jun;:114707 72. [IF=8.5] Yunyi Chen et al."Hepatoprotective potential of four fruit extracts rich in different structural flavonoids against alcohol-induced liver injury via gut microbiota-liver axis."FOOD CHEMISTRY.2024 Dec;460:140460 71. [IF=1.8] Na Li et al."Ultra-high-performance liquid chromatography–mass spectrometry combined with molecular docking and molecular dynamics simulation reveals the source of bitterness in the traditional Chinese medicine formula Runchang-Tongbian."BIOMEDICAL CHROMA 70. [IF=3.4] Zhao Xiaona et al."Investigation the differences in key taste-contributing substances between Shitougan(Citrus reticulata Blanco Cv. Manau Gan) and other citrus varieties."Journal of Food Measurement and Characterization".2024 May;:1-13 69. [IF=4.3] Nawei Zhang et al."Factors affecting the formation of delayed bitterness in sweet orange (Citrus sinensis (L.) Osbeck) juice."JOURNAL OF FOOD COMPOSITION AND ANALYSIS".2024 Aug;132:106298 68. [IF=3.9] Qijian Xu et al."Comprehensive quality evaluation of fermented-steaming Fructus Aurantii based on chemical composition, flavor characteristics, and intestinal microbial community."JOURNAL OF FOOD SCIENCE".2024 Apr;: 67. [IF=4.6] Wang Hong-Ping et al."Comprehensive identifying flavonoids in Citri Reticulatae Pericarpium using a novel strategy based on precursor ions locked and targeted MS/MS analysis."Scientific Reports".2024 Apr;14(1):1-9 66. [IF=2.7] Tong Wang et al."Flavonoids from Citrus reticulata: Inhibitory activity against pathogenic fungi and biocontrol potential."PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY".2024 May;131:102250 65. [IF=6] Jianping Jiang et al."The optimization of extraction process on Quzhou Fructus Aurantii flavonoids with natural deep eutectic solvents: A comparative study between orthogonal analysis and genetic neural network."LWT-FOOD SCIENCE AND TECHNOLOGY".2024 Apr;1 64. [IF=6.1] Yu Liang et al."Scavenging Glyoxal and Methylglyoxal by Synephrine Alone or in Combination with Neohesperidin at High Temperatures."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY".2024;XXXX(XXX):XXX-XXX 63. [IF=4.6] Yu Yan et al."Antibacterial Activity and Mechanisms of Plant Flavonoids against Gram-Negative Bacteria Based on the Antibacterial Statistical Model."Pharmaceuticals".2024 Mar;17(3):292 62. [IF=5.2] Dan Wu et al."Optimizing the Solvent Selection of the Ultrasound-Assisted Extraction of Sea Buckthorn (Hippophae rhamnoides L.) Pomace: Phenolic Profiles and Antioxidant Activity."Foods".2024 Jan;13(3):482 61. [IF=6.1] Yu Liang et al."Scavenging Glyoxal and Methylglyoxal by Synephrine and Neohesperidin from Flowers of Citrus aurantium L. var. amara Engl. in Mice and Humans."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY".2024;72(14):8027–8038 60. [IF=5.4] Zhaoyi Ye et al."Zhi-Zi-Hou-Po decoction alleviates depressive-like behavior and promotes hippocampal neurogenesis in chronic unpredictable mild stress induced mice via activating the BDNF/TrkB/CREB pathway."JOURNAL OF ETHNOPHARMACOLOGY.2024 Jan;319:117355 59. [IF=4.3] Ye Gu et al."Using pectinase enzymatic peeling for obtaining high-quality Huyou (Citrus changshanensis) segments."JOURNAL OF FOOD COMPOSITION AND ANALYSIS.10.1016/j.jfca.2023.105706 58. [IF=4.5] Guangtao Pan et al."Dachengqi decoction ameliorates sepsis-induced liver injury by inhibiting the TGF-β1/Smad3 pathways."Journal of Traditional and Complementary Medicine.10.1016/j.jtcme.2023.09.001 57. [IF=7.9] Sheng Zhang et al."A phytomedicine extract exerts an anti-inflammatory response in the lungs by reducing STING-mediated type I interferon release."PHYTOMEDICINE.2024 Jan;:155373 56. [IF=5.6] Lihong Ye et al."Si-Ni-San alleviates early life stress-induced depression-like behaviors in adolescence via modulating Rac1 activity and associated spine plasticity in the nucleus accumbens."Frontiers in Pharmacology.2023; 14: 1274121 55. [IF=2] Huixian Zhou et al."Metabolic profiling of the flower of Citrus aurantium L. var. amara Engl. in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight tandem mass spectrometry with data mining strategy."RAPID COMMUNI 54. [IF=5] Tianzhu Guan et al."In vitro and in silico perspectives on the activation of antioxidant responsive element by citrus-derived flavonoids."Frontiers in Nutrition.2023; 10: 1257172 53. [IF=5.7] Na Shang et al."Crc1,6RhaT is involved in the synthesis of hesperidin of the main bioactive substance in the Citrus reticulata ‘Chachi’ fruit."Horticultural Plant Journal.2023 Jul;: 52. [IF=2.6] Ting Yang et al."Determination of Ten Flavonoids in the Raw and Fermented Fructus Aurantii by Quantitative Analysis of Multicomponents via a Single Marker (QAMS) Based on UPLC."Journal of Analytical Methods in Chemistry.2023;2023:6067647 51. [IF=1.967] ke Zunli et al."Physicochemical characteristics, polyphenols and antioxidant activities of Dimocarpus longan grown in different geographical locations."ANALYTICAL SCIENCES.2023 Apr;:1-8 50. [IF=6.317] Lufang Chen et al."3D-QSAR studies on the structure–bitterness analysis of citrus flavonoids."Food & Function.2023 Apr;: 49. [IF=0.816] Li Han et al."Fluorescence Studies on Flavonoid Diglycosides and Corresponding Deglycosylated Monoglycosides."Journal of Applied Spectroscopy.2023 Mar;90(1):232-238 48. [IF=6.633] Qiufang Bai et al."Enantioselective separation and simulation studies of five flavanone glycosides on a cellulose tris-(3,5-dichlorophenylcarbamate) chiral stationary phase."JOURNAL OF MOLECULAR LIQUIDS.2023 Mar;374:121260 47. [IF=9.221] Wei Lan et al."Rapid visual discrimination of Citri Reticulatae Pericarpium from different origins by fluorescent sensors based on aluminum ions and Ag nanoclusters."SENSORS AND ACTUATORS B-CHEMICAL.2023 Apr;380:133329 46. [IF=3.654] Wenfeng Li et al."Inhibition characteristics and mechanism of tyrosinase using five citrus flavonoids: A spectroscopic and molecular dynamics simulation study."JOURNAL OF FOOD BIOCHEMISTRY.2022 Oct;:e14484 45. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199 44. [IF=6.208] Pan Wang et al."Discovery of Flavonoids as Novel Inhibitors of ATP Citrate Lyase: Structure–Activity Relationship and Inhibition Profiles."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2022 Jan;23(18):10747 43. [IF=6.656] Di Deng et al."Sinisan alleviates depression-like behaviors by regulating mitochondrial function and synaptic plasticity in maternal separation rats."PHYTOMEDICINE.2022 Aug;:154395 42. [IF=3.949] Jiang Anze et al."Effects of Fruit Bagging on the Physiochemical Changes of Grapefruit (Citrus paradisi)."Food Quality and Safety.2022 Jul;: 41. [IF=6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure–Activity Relationship, Kinetics and Interaction Mechanism."Frontiers in Nutrition. 2022; 9: 892426 40. [IF=3.935] Junmao Li et al."Comprehensive chemical profiling of the flowers of Citrus aurantium L. var. amara Engl. and uncovering the active ingredients of lipid lowering."J Pharmaceut Biomed. 2022 Mar;211:114621 39. [IF=2.629] Mu Qixuan et al."Study on Closely Related Citrus CMMs based on Chemometrics and Prediction of Components-Targets-Diseases Network by Ingenuity Pathway Analysis."Evid-Based Compl Alt. 2022;2022:1106353 38. [IF=2.391] Tan Si et al."Effects of three drying methods on polyphenol composition and antioxidant activities of Litchi chinensis Sonn.."Food Sci Biotechnol. 2020 Mar;29(3):351-358 37. [IF=3.216] Shuai Yuan et al."Neohesperidin Ameliorates Steroid-Induced Osteonecrosis of the Femoral Head by Inhibiting the Histone Modification of lncRNA HOTAIR."Drug Des Dev Ther. 2020; 14: 5419–5430 36. [IF=3.361] Yanhui Zhao et al."Rapid characterization of the chemical constituents of Sanhua decoction by UHPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry."Rsc Adv. 2020 Jul;10(44):26109-26119 35. [IF=4.357] Wang Si-wei et al."Neohesperidin enhances PGC-1α-mediated mitochondrial biogenesis and alleviates hepatic steatosis in high fat diet fed mice."Nutr Diabetes. 2020 Aug;10(1):1-11 34. [IF=4.411] Liuyi Yu et al."Systematic Detection and Identification of Bioactive Ingredients from Citrus aurantium L. var. amara Using HPLC-Q-TOF-MS Combined with a Screening Method."Molecules. 2020 Jan;25(2):357 33. [IF=4.534] Chuanxin Zhang et al."Neohesperidin promotes the osteogenic differentiation of human bone marrow stromal cells by inhibiting the histone modifications of lncRNA SNHG1."Cell Cycle. 2021;20(19):1953-1966 32. [IF=4.952] Yan Tian et al."Interaction between pH-shifted β-conglycinin and flavonoids hesperetin/hesperidin: Characterization of nanocomplexes and binding mechanism."Lwt Food Sci Technol. 2021 Apr;140:110698 31. [IF=4.952] Si Tan et al."The effects of drying methods on chemical profiles and antioxidant activities of two cultivars of Psidium guajava fruits."Lwt Food Sci Technol. 2020 Jan;118:108723 30. [IF=5.162] Naymul Karim et al."Surface decoration of neohesperidin-loaded nanoliposome using chitosan and pectin for improving stability and controlled release."Int J Biol Macromol. 2020 Dec;164:2903 29. [IF=5.279] Jiajing Chen et al."Primary Bitter Taste of Citrus is Linked to a Functional Allele of the 1,2-Rhamnosyltransferase Gene Originating from Citrus grandis."J Agr Food Chem. 2021;69(34):9869–9882 28. [IF=5.34] Jing Zhang et al."Application of “spider-web” mode in discovery and identification of Q-markers from Xuefu Zhuyu capsule."Phytomedicine. 2020 Oct;77:153273 27. [IF=6.529] Yuqi Ying et al."Pharmacokinetic-Pharmacodynamic Modeling of the Antioxidant Activity of Quzhou Fructus Aurantii Decoction in a Rat Model of Hyperlipidemia."Biomed Pharmacother. 2020 Nov;131:110646 26. [IF=6.543] Wang Yue et al."Polymethoxyflavones in Citrus Regulate Lipopolysaccharide-Induced Oscillating Decay of Circadian Rhythm Genes by Inhibiting Nlrp3 Expression."Oxid Med Cell Longev. 2021;2021:8419415 25. [IF=6.953] Naymul Karim et al."Suppression of palmitic acid-induced hepatic oxidative injury by neohesperidin-loaded pectin-chitosan decorated nanoliposomes."Int J Biol Macromol. 2021 Jul;183:908 24. [IF=7.053] Mohammad Rezaul Islam Shishir et al."Pectin-chitosan conjugated nanoliposome as a promising delivery system for neohesperidin: Characterization, release behavior, cellular uptake, and antioxidant property."Food Hydrocolloid. 2019 Oct;95:432 23. [IF=7.514] Jing Zhao et al."A sensitive and practical ELISA for analyzing naringenin in pummelo and herb samples."Food Chem. 2021 Nov;362:130223 22. [IF=5.81] Zhang Xianhua et al."Pharmacokinetic Study of 7 Compounds Following Oral Administration of Fructus Aurantii to Depressive Rats."Front Pharmacol. 2018 Mar;0:131 21. Zhang, Jing, et al. "Application of “spider-web” mode in discovery and identification of Q-markers from Xuefu Zhuyu capsule." Phytomedicine 77 (2020): 153273.https://doi.org/10.1016/j.phymed.2020.153273 20. Zhang X, Han L, Liu J, et al. Pharmacokinetic Study of 7 Compounds Following Oral Administration of Fructus Aurantii to Depressive Rats. Frontiers in Pharmacology. 2018 ;9:131. DOI: 10.3389/fphar.2018.00131. PMID: 29556193; PMCID: PMC5845165. 19. Wang, Sw., Sheng, H., Bai, Yf. et al. Neohesperidin enhances PGC-1α-mediated mitochondrial biogenesis and alleviates hepatic steatosis in high fat diet fed mice. Nutr. Diabetes 10, 27 (2020). https://doi.org/10.1038/s41387-020-00130-3 18. Naymul Karim, Mohammad Rezaul Islam Shishir, Wei Chen, Surface decoration of neohesperidin-loaded nanoliposome using chitosan and pectin for improving stability and controlled release, International Journal of Biological Macromolecules, Volume 164, 2020, P 17. 张雪,朱子豪,章博,郭兴杰.纤维素键合手性固定相法分离5种黄烷酮糖苷类药物异构体[J].沈阳药科大学学报,2020,37(10):903-907. 16. 彭芳芳,林桂梅.枳实生制品提取液中黄酮类成分及其单体在Caco-2细胞模型中的吸收转运研究[J].中华中医药学刊,2021,39(01):107-110. 15. 薛梦洁,于卉娟,王璐瑶,柴欣,杨静,王跃飞.血府逐瘀汤提取过程中成分的量变规律研究[J].天津中医药,2021,38(01):109-112. 14. 刘嘉丽,刘德明,王丹,张鸿,董新荣,童建华.湖南柑橘果皮总黄酮及橙皮苷含量分析[J].湖南农业科学,2020(11):58-62. 13. ]赵衍辉,刘婷婷,满靖怡,王淼,赵旻,赵春杰.HPLC法同时测定三化汤中7种成分的含量[J].沈阳药科大学学报,2021,38(03):272-278. 12. 戚华文,徐鑫,温柔,高德嵩,王超然,刘艳芳,金红利,梁鑫淼.基于化学模式识别技术的枳实HPLC定量指纹图谱研究[J].分析测试学报,2021,40(01):72-78. 11. 董丽萍, 赵家莹, 詹梁,等. 经典名方温胆汤中枳实模拟古法的炮制工艺与质量控制研究[J]. 上海中医药杂志, 2019, v.53;No.597(10):96-102. 10. 许守超, 陈屠梦, 包绍印,等. 基于响应面试验设计优选衢枳壳多指标成分工艺研究[J]. 中药材 2019年42卷11期, 2617-2621页, MEDLINE ISTIC PKU, 2020. 9. 邓可众 陈虹 熊艺 等. 不同产地及不同采收期江枳实的UPLC指纹图谱研究[J]. 中药材 2017 040(009):2051-2054. 8. 沈虹 邓可众 钟志奎 等. HPLC法同时测定酸橙花的多成分含量及不同花期的质量分析[J]. 中药材 2018 041(008):1914-1917. 7. 郭琳 黄平情 于颖超 等. HPLC法同时测定胃康宁颗粒中5种成分的含量[J]. 中华中医药杂志 2020 v.35(01):139-142. 6. 黄湘 陈丰连 曹骋 等. HPLC-ELSD全成分指纹图谱研究疏肝理脾方配伍前后化学成分的变化[J]. 化学与生物工程 2020 037(001):59-64. 5. 梁琰, 张贵民, 苏瑞强,等. 小儿消积止咳口服液多指标成分分析及其HPLC指纹图谱研究[J]. 中草药, 2017(21):79-86. 4. 姚东, 孟宪生, 王帅,等. 气滞胃痛颗粒全时段多波长融合指纹图谱研究及多成分定量分析[J]. 中国中药杂志, 2013, 38(10):1513. 3. 尹丽波, 赵启苗, 林桂梅,等. 枳实软化和切制的工艺研究[J]. 亚太传统医药, 2012(01):31-35. 2. 马雪松, 邹兵, 尹丽波,等. 多指标优选麸炒枳实的炮制工艺研究[J]. 中国医药指南, 2012, 010(009):72,74. 1. 邓可众 邓敏芝 熊英 等. HPLC法同时分析酸橙果实类药材中黄酮和香豆素类成分[J]. 中药材 2016年39卷3期 575-578页 MEDLINE ISTIC PKU 2016.